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Full Screen- Title
- Declaration
- Certificate
- Acknowledgement
- Abstract
- Preface
- Contents
- List of Tables
- List of Figures
- List of Abbreviations
- 1. Review of literature
- 1.1 Mitochondria
- 1.2 The TCA cycle
- 1.3.The Electron Transport chain and Oxidative phosphorylation
- 1.4.Inhibitors of Oxidative Phosphorylation
- 1.5.Mitochondrial DNA
- 1.6.Role of mitochondria in programmed cell death
- 1.7.Free Radicals
- 1.8.Damages produced by the free radicals
- 1.9.Antioxidant defenses in body
- 1.10.Oxidative Stress
- 1.11.Oxidative stress and mitochondrial damage
- 1.12.Role of mitochondria in aging
- 1.13.Role of mitochondria in diseases
- 1.14.Therapeutical interventions or antioxidants used to combat against oxidative stress and aging and resultant cellular damages
- 1.15.Mitochondrial medicine
- 1.16.Importance of fungi
- 1.17.Ganoderma lucidum
- 2. Materials and Methods
- 3. Antioxidant activity of aqueousethanol (70% ethanol) extract of Ganoderma lucidum, protein bound polysaccharides and total triterpenes
- 4 Evaluation of the effect of Ganoderma lucidum extract on mitochondrial oxidative stress and dysfunction during aging
- 5. Effect of protein bound polysaccharides isolated from the Ganoderma lucidum on the mitochondrial oxidative stress and dysfunction in old aged rats
- 6. Effect of total triterpenes isolated from the Ganoderma lucidum on the mitochondrial oxidative stress and dysfunction in old aged rats
- 7. Effect of Ganoderma lucidum on the chemical induced mitochondrial oxidative stress and dysfunction
- 7A. Effect of Ganoderma lucidum on the isoproterenol induced cardiac mitochondrial oxidative stress and dysfunction
- 7B. Effect of Ganoderma lucidum on the acetaminophen induced hepatic mitochondrial oxidative stress and dysfunction
- 7C. Effect of Ganoderma lucidum on the carbon tetrachloride induced hepatic mitochondrial oxidative stress and dysfunction
- 8. Toxicity studies of aqueous-ethanol extract of Ganoderma lucidum, protein bound polysaccharides and total triterpenes
- 9. Preliminary phytochemical analysis of aqueous-ethanol extract of Ganoderma lucidum, protein bound polysaccharides and total triterpenes
- Summary and Conclusion
- Bibliography