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Title
DEDICATION
CERTIFICATE 1
CERTIFICATE-2
DECLARATION
ACKNOWLEDGEMENT
ABBREVIATIONS
CONTENTS
1 Introduction
Table 1.1 Human viruses with oncogenic properties
Table 1.2 Chemicals with proven carcinoeenic activity - in humans
Fig. 1.2 Structure of hydrophilic non-enzymatic antioxidants (a) Ascorbate (b Reduced glutathione
Fig. 1.3 Mechanism by which free radicals damage cells
2 Review of Literature
3 Materials and Methods
A. Experimental Animals
B. Aflatoxin- B, Preparation
C. Tumour Cell Line and Their Maintenance
D. Preparation of Retinyl Acetate
E. Study of Survival Period
F. Grouping of Animals for Hepatoma Study
G. Grouping of Animals for Daltons Lymphoma Study
H. Methods Used for the Biochemical Analysis
I. Estimation of Ascorbic Acid
II. Estimation of Glutathione (Reduced)
III. Estimation of Superoxide Dismutase
IV. Estimation of Catalase
V. Estimation of Glutathione-S-Transferase
VI. Estimation of Protein
VIII. Estimation of Serum Lactate Dehydrogenase
IX. Estimation of Serum Transan~inases
X. Estimation of Serum Phosphatases
1. Alkaline phosphatase
2. Acid phosphatase
I. Statistical Analysis
4 Results and Discussion
Section 1
1.1 Survival Period in Aflatoxin B, -induced Hepatoma Bearing Mice
1.2. Antioxidants in Aflatoxin-induced Hepatoma
1.3. Antioxidant and Detoxifying Enzymes in Aflatoxin-induced Hepatoma
1.4. Liver Enzymes in Aflatoxin-induced Hepatoma
1.5 Effect of Retinyl Acetate in Aflatoxin-induced Hepatoma
1.5a. Effect of retinyl acetate on antioxidants
1.5b. Effect of retinyl acetate on antioxidant and detoxifying enzymes
1.5c. Effect of retinyl acetate on liver enzymes
1.5d. Effect of retinyl acetate on the histopathology of hepatomic liver
Photograph 1&2 G1 and G2 showing the whole liver of normal control mouse and hepatoma bearing untreated mouse respectively
Photographs 3, 4 & 5 Showing the whole liver of retinyl acetate (10mg, 50mg, and 100 mg/day/mouse respectively) treated groups
Photograph 6&7 Showing the histopathological sections of normal control mouse and hepatoma bearing untreated mouse respectively
Photographs 8, 9 & 10 G3, G4 and G5 showing the histopathological sections of retinyl acelate (10mg, 50mg, and 100mg/day/mouse respectively) treated groups
1.6 General Discussion Section 2
Section 2
2.1 Survival Period in Daltons Lymphoma Bearing Mice
2.2. Antioxidants in Daltons Lymphoma
2.3. Antioxidant and Detoxifying Enzymes in Daltons Lymphoma
2.4. Liver Enzymes in Daltons Lymphoma
2.5. Effect of Retinyl Acetate on Daltons Lymphoma
2.5a. Effect of retinyl acetate on antioxidants
2.5b Effect of retinyl acetate on antioxidant and detoxifying enzymes
2.5c. Effect of retinyl acetate on liver enzymes
2.6. General Discussion
5 Summary
References