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TITLE
CERTIFICATE-I
CERTIFICATE-II
DECLARATION
ACKNOWLEDGEMENT
DEDICATION
CONTENTS
ABBREVIATIONS
1. LACTOFERRIN: AN UNFINISHED AGENDA
This dissertation reports: -
2. REVIEW OF LITERATURE
2.1 Transferrins: Biological and PhylogeneticDistribution
2.2 Physical Structure of Lactoferrin
2.3 Folding Stability
2.4 Glycosyl Moieties of Lactoferrins
2.5 Functions of Lactoferrin
2.6 Functional Fragments of Lactoferrin
2.7 Porcine Lactoferrin: Studies Done So Far
3. lCOMPREHENSIVE SEQUENCEANALYSIS OF THE TRANSFERRINFAMILY OF PROTEINS
3.1 Introduction
3.2 Resources
3.3 Sequence Conservation Among Lactoferrins
3.4 Transferrin Proteins Together: The SequenceVariability
3.5 Phytogeny of Transferrin Proteins: ComplexPatterns
CONCLUSIONS
4. PORCINE LACTOFERRIN: PURIFICATION, PREPARATION OF MONOFERRIC FUNCTIONAL LOBES AND REASSOCIATED NFe-CFe LOBE COMPLEX
4.1 IntroductionLactoferrins are generally
4.2 Materials and Methods
4.3 Results
4.4 Discussion
CONCLUSIONS
5. IRON- RELEASE BEHAVIOUR AND THE NATURE OF DOMAIN- INTERACTIONS OF PORCIENIE LACTOFERRIN
5.1 introduction
5.2 Materials and Methods
5.3 Results
5.4 Discussion
CONCLUSIONS
6. CRYSTALLIZATION OF PORCINELACTOFERRIN
6.1 Introduction
6.2 Materials and Methods
6.3 Results
6.4 Discussion
CONCLUSIONS
7. THERMAL UNFOLDING OF PORCINE LACTOFERRIN; DIFFERENTIAL SCANNING CALORIMETRIC STUDIES
7.1 introduction
7.2 Structure and Unfolding of Protein
7.3 Differential Scanning Calorimetry and ProteinUnfolding
7.4 Materials and Methods
7.5 Results
7.6 Discussion
CONCLUSIONS
REFERENCES