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Full Screen- Title
- CERTIFICATE 1
- CERTIFICATE-2
- DECLARATION
- ACKNOWLEDGEMENT
- CONTENTS
- ABBREVIATIONS
- Preface
- I Magnet and Magnetic Field
- References
- II Bioeffects of Magnetic Field- A Review
- 2.1 Historical Background
- 2.2 Bioeffects of Static and Electromagnetic Field
- 2.3 Geomagnetic Field Biological Interaction
- Reference
- III Therapeutic Application of Magnetic Field
- 3.1 Pharmacological Application in Modern Medicine
- Reference
- IV Artherosclerosis
- 4.1 Origin and Progression
- 4.2 Oxidative Damage and Pathogenesis
- 4.2. (a) Biological Effects of Free Radicals
- 4.2.a (1) Interaction with Lipicl - Lipid peroxidation
- 4.2.a (2) Interaction with Nucleic: Acid
- 4.2.a (3) lnteraction with Proteir~
- 4.3 Defense against ROS-Catalytic Removal of ROS by Antioxicant Enzymes and Antioxidants
- 4.3.1 Primary Defense Against Reactive Oxygen Species (ROS)
- 4.3.1 (a) Super Oxide Dismutase (SOD)
- 4.3.1 (b) Catalase
- 4.3.1 (c) Glutathione Peroxidase (GSH-Px)
- 4.3.1 (d) Antioxidants
- 4.3.2 Secondary Defenses Against Reactive Oxygen Species (ROS)
- Reference
- V Exploration of Effective Field Strength
- 5.1 Grouping of Animals for Screening Study
- 5.1 (1) Section - l
- 5.1 (2) Section - II
- 5.1 (3) Section - Ill
- 5.1 (4) Section - IV
- References
- VI Methodology Related to the Evaluation of Atherosclerosis
- 6.1 Grouping of Animals for Experimental Study
- 6.2 Preparation of Serum and Tissue Samples for Biochemical Study
- 6.3 Methods used for the Biochemical Study
- 6.3.A Extraction of Serum and Tissue for Lipids
- 6.3.B Extraction of Serum; or Lipids
- 6.3.C Estimation of Lipitis
- 6.3.C (1) Estimation of Ct~olesterol
- 6.3.C (2) Estimation of Total Lipids
- 6.3.C (3) Estimation of Phospholipids
- 6.3.C (4) Estimation of Triglycerides
- 6.3.D Lipoproteins
- 6.3.E Ascorbic Acid and Cilutathione (GSHHAntioxidants)
- 6.3.E (1) Estimation of Ascorbic A cid
- 6.3.E (2) Estimation of Glutathione (GSH)
- 6.3.F Superoxide Dismutase (SOD), Catalase, GlutathionePeroxidase (GSH- px) - (Antioxidant Enzymes)
- 6.3.F (1) Estimation of Supc?roxide Dismutase
- 6.3.F (2) Estimation of Catalase
- 6.3.F (3) Estimation of Glutathione Peroxidase (GSH-Px)
- 6.3.F (4) GSH Estimation l) y the Method of Beutler and ~ e l l e
- 6.3.G Glutathione-S-transferase (GST), Glutathione Reductase (GR) - (Detoxifying Enzymes)
- 6.3.G (1) Estimation of Glutathione-S-Transferase (GST)
- 6.3.G (2) Estimation of Glutathione Reductase (GR)
- 6.3.H Lipid Peroxidatic~nP roducts-Malondialdehyde (MDA) andConjugated Dienes (CD)
- 6.3.H (1) Estimation of Malondialdehyde (MDA)
- 6.3.H (2) Estimation of Conjugated dienes (CD)
- 6.3.I γGlutamyl Transpeptidase, (GGT), Lactate Dehydrogenasi? (LDH), Transamitlases [Aspartarte transaminase (AST) andAlanine Transalninase (ALT) ], Phosphatases [AlkalinePhosphatase (ALP), Acid Phosphatase (ALP) ] in Serum.
- 6 3 (1) Estimation of; -Glutamyl Transpeptidase (GGT)
- 6.3.1 (2) Estimation Serum Lactate Dehydrogenase
- 6.3.1 (3) Estimation of Ser~m Transaminases
- 6.3.1 (4) Estimation of !serum Phosphatases
- 6.3.J. Hydroxymethyl Glutaryl Co.A ReductasHHMG Co.AReductase), Glucose-Gphosphate Dehydrogenase (G4-P-D), Lactate Dehydrogenase (LDH), Lipoprotein Lipase andTriglyceride Lipase in Tissues
- 6.3.J. (1) Assay of HMG Co.A Reductase
- 6.3.J (2) Assay of Glucose-6- Phosphate Dehydrogenase (G-6-PD)
- 6.3.J (3) Lactate Dehydrogenase (LDH)
- 6.3.J (4) Estimation of Lipoprotein Lipase and Triglyceride Lipases
- 6.3.K Serum lron and l n ~Bni nding Capacity
- 6.3.K (1) Estimation of Serum lron
- 6.3.K (2) Estimation of Serum lron Binding Capacity
- 6.3.L. Estimation of Hemoglobin And Red Blood Cell Count (RBCCount)
- 6.3.L (1) Estimation of Herloglobin
- 6.3.L (2) Total RBC count
- 6.3.M Estimation of Proteins
- 6.3.N. Estimation of Tissue Calcium
- Statistical Analyses
- References
- VII Magnetic Field and Atherosclerosis-A Therapeutic Approach
- 7.1 Results
- I. Study of body weight, organ weight and organ wt./body wt ratio of normal and atherogenic rats exposed to 3000 Gauss magnetic field 4hrs / day for 45 days
- II. Effect of Magnetic Field (3000 Gauss) on Lipid Metabolism
- Ill. Effect of Magnetic field (3000 Gauss) on Free radical Metabolism
- IV. Effects of Magnetic field on Hematological Parameters
- V. Variation in the activity of clinically important enzymesunder 3000 Gauss magnetic field
- VI. Calcium levels in normal and atherogenic rats.
- 7.2 Discussion
- 7.2.1 Lipids in Atherosclerosis and Magnetotherapy
- 7.2.2 Reactive Oxygen Species (ROS) in Atherosclerosis andMagneto Therapy
- References
- VIII Major Findings