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  • Title
  • Certificate
  • Declaration
  • Dedication
  • Acknowledgement
  • Abstract
  • Preface
  • Table of Contents
  • List of Figures
  • List of Tables
  • Abbreviations
  • 1. Review of literature
  • 1.1. Cancer statistics
  • 1.2. Acquired functional capabilities of cancer cells
  • 1.3.Tthe characteristics of cancer cells
  • 1.4.M molecular basis of cancer
  • 1.5. Apoptosis and cancer
  • 1.6. Reactive oxygen species and cancer
  • 1.7. Cancer therapy
  • 1.8. Inflammation and cancer
  • 1.9. Plant derived anticancer agents
  • 1.10. Importance of biotechnology in the propagation of medicinal plants
  • 1.11. Dasamoola
  • 2. Materials and Methods
  • 2.2.1. Preparation of extract
  • 2.2.2. Micro propagation
  • 2.2.3. Determination of in vitro antioxidant activity
  • 2.2.4. Determination of anti inflammatory activities
  • 2.2.5. Short-term cytotoxic activity
  • 2.2.6. Biochemical analysis
  • 2.2.7. Histopathology
  • 3. Micropropagation of Solanum xanthocarpum and Tribulus terrestris and comparison of their chemical profile with ex vitro plants
  • 3 1. Micropropagation of Solanum xanthocarpum and Tribulus terrestris
  • 3.1.1. Micropropagation of Solanum xanthocarpum
  • 3.1.2. Micropropagation of Tribulus terrestris
  • 3.2. Phytochemical screening of ex vitro and in vitro propagated plants of Solanum xanthocarpum and Tribulus terrestris
  • 4. Anticancer activities of Solanum xanthocarpum and Tribulus terrestris
  • 4.1. Anti oxidant activity of Solanum xanthocarpum and Tribulus terrestris and their comparison with micropropagated plants
  • 4.2. Anti inflammatory activity of Solanum xanthocarpum and Tribulus terrestris
  • 4.3. Cytotoxicity of Solanum xanthocarpum and Tribulus terrestris and their comparison with micropropagated plants
  • 4.4. Anti tumor activity of Solanum xanthocarpum and Tribulus terrestris
  • 5. Mechanism of anti cancer activities of Solanum xanthocarpum and Tribulus terrestris
  • 6. Protective activities of Solanum xanthocarpum and Tribulus terrestris
  • 6.1. Gastroprotective activities of Solanum xanthocarpum and Tribulus terrestris
  • 6.2. Protective effect of Solanum xanthocarpum and Tribulus terrestris on cisplatin induced nephrotoxicity
  • 6.3. Protective activityof Solanum xanthocarpum and Tribulus terrestris against doxorubicin induced cardiotoxicity, nephrotoxicity and hepatotoxicity
  • 7. Summary and Conclusions
  • Bibliography