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Full Screen- TITLE
- CERTIFICATE
- DECLARATION
- DEDICATION
- PREFACE
- ACKNOWLEDGEMENT
- CONTENTS
- ABBREVIATIONS
- 1. INTRODUCTION AND OBJECTIVES
- REFERENCES
- 2. POLYMER- SUPPORTED SOLID PHASE REACTIONS: AN OVERVIEW
- 2.1 Polymer support
- 2.2 Nature of the support
- 2.3 Linear and crosslinked supports
- 2.4 Problems faced in polymer supported solid phase reactions
- 2.5 Diffusion of solvents into the polymer matrix
- 2.6 Principle and strategy of solid phase peptide synthesis
- 2.7 Recent techniques in solid phase peptide synthesis
- 2.8 Sequential attachment of amino acids and deprotection
- 2.9 Cleavage
- REFERENCES
- 3. STRUCTURE-REACTIVITY CORRELATIONS IN CROSSLINKED POLY (N-VINYLPYRROLIDONES)
- 3.1 Results and Discussion
- Fig. 3.4 Scanning electron micrograph of 5% TEGDMA crosslinked Poly (N-vinyl pyrrolidone)
- Fig.3.8 Scanning electron micrograph of 3% DVB crosslinked PVP
- 3.2 Preparation of bromine complex of crosslinked polyvinyl pyrrolidone
- 3.3 Variation of bead size with polymerisation condition
- Fig.3.19 Model showing the formation of crosslinked polymer beads
- 3.4 Variation of porosity with reaction condition
- Fig.3.22 Scanning electron micrographs showing the variation of porosity of crosslinked polymer beads
- Fig.3.23 Scanning electron micrograph showing the rigid matrix of 20% TEGDMA crosslinked PVP
- Fig.3.24 Scanning electron micrograph of 10% NNMBA crosslinked polymer showing the craters at the surface
- Fig.3.25 The scanning electron micrograph showing the closed structure of 3% DVB crosslinked polymer
- 3.5 Effect of diluent
- Fig.3.26 Scanning electron micrograph showing the porous structure of 5% TEGDMA crosslinked PVP prepared in presence of 10% and 50% toluene as diluent
- Fig.3.27 Scanning electron micrograph of 5% TEGDMA crosslinked polymer prepared in presence of hexane as diluent
- 3.6 Reaction kinetics using differently crosslinked beads
- Fig.3.28 Crosslinked structure of a polymer gel showing effective chains of the structure defined by the crosslinks
- Fig.3.31 Scanning electron micrograph of 50% TEGDMA crosslinked PVP
- 3.7 Experimental
- References
- 4. PEPTIDE SYNTHESIS ON PS-NVP-HDODA RESIN
- 4.1 Results and discussion
- 4.2 Stability of the polymer
- 4.3 Resin functionalisation
- 4.4 Swelling characteristics of the resin
- 4.5 Linker incorporation to the resin
- 4.6 C-terminal amino acid incorporation
- 4.7 Solid phase peptide synthesis using Boc- amino acids
- 4.8 Manual peptide synthesis using Fmoc- amino acids
- 4.9 Experimental procedure
- References
- 5. SUMMARY AND OUTLOOK