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Full Screen- Title
- DEDICATION
- CERTIFICATE 1
- CERTIFICATE-2
- DECLARATION
- ACKNOWLEDGEMENT
- ABBREVIATIONS
- CONTENTS
- 1 Introduction
- Table 1.1 Human viruses with oncogenic properties
- Table 1.2 Chemicals with proven carcinoeenic activity - in humans
- Fig. 1.2 Structure of hydrophilic non-enzymatic antioxidants (a) Ascorbate (b Reduced glutathione
- Fig. 1.3 Mechanism by which free radicals damage cells
- 2 Review of Literature
- 3 Materials and Methods
- A. Experimental Animals
- B. Aflatoxin- B, Preparation
- C. Tumour Cell Line and Their Maintenance
- D. Preparation of Retinyl Acetate
- E. Study of Survival Period
- F. Grouping of Animals for Hepatoma Study
- G. Grouping of Animals for Daltons Lymphoma Study
- H. Methods Used for the Biochemical Analysis
- I. Estimation of Ascorbic Acid
- II. Estimation of Glutathione (Reduced)
- III. Estimation of Superoxide Dismutase
- IV. Estimation of Catalase
- V. Estimation of Glutathione-S-Transferase
- VI. Estimation of Protein
- VIII. Estimation of Serum Lactate Dehydrogenase
- IX. Estimation of Serum Transan~inases
- X. Estimation of Serum Phosphatases
- 1. Alkaline phosphatase
- 2. Acid phosphatase
- I. Statistical Analysis
- 4 Results and Discussion
- Section 1
- 1.1 Survival Period in Aflatoxin B, -induced Hepatoma Bearing Mice
- 1.2. Antioxidants in Aflatoxin-induced Hepatoma
- 1.3. Antioxidant and Detoxifying Enzymes in Aflatoxin-induced Hepatoma
- 1.4. Liver Enzymes in Aflatoxin-induced Hepatoma
- 1.5 Effect of Retinyl Acetate in Aflatoxin-induced Hepatoma
- 1.5a. Effect of retinyl acetate on antioxidants
- 1.5b. Effect of retinyl acetate on antioxidant and detoxifying enzymes
- 1.5c. Effect of retinyl acetate on liver enzymes
- 1.5d. Effect of retinyl acetate on the histopathology of hepatomic liver
- Photograph 1&2 G1 and G2 showing the whole liver of normal control mouse and hepatoma bearing untreated mouse respectively
- Photographs 3, 4 & 5 Showing the whole liver of retinyl acetate (10mg, 50mg, and 100 mg/day/mouse respectively) treated groups
- Photograph 6&7 Showing the histopathological sections of normal control mouse and hepatoma bearing untreated mouse respectively
- Photographs 8, 9 & 10 G3, G4 and G5 showing the histopathological sections of retinyl acelate (10mg, 50mg, and 100mg/day/mouse respectively) treated groups
- 1.6 General Discussion Section 2
- Section 2
- 2.1 Survival Period in Daltons Lymphoma Bearing Mice
- 2.2. Antioxidants in Daltons Lymphoma
- 2.3. Antioxidant and Detoxifying Enzymes in Daltons Lymphoma
- 2.4. Liver Enzymes in Daltons Lymphoma
- 2.5. Effect of Retinyl Acetate on Daltons Lymphoma
- 2.5a. Effect of retinyl acetate on antioxidants
- 2.5b Effect of retinyl acetate on antioxidant and detoxifying enzymes
- 2.5c. Effect of retinyl acetate on liver enzymes
- 2.6. General Discussion
- 5 Summary
- References