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  • TITLE
  • CERTIFICATE
  • DECLARATION
  • ACKNOWLEDGEMENT
  • DEDICATION
  • CONTENTS
  • 1. CHLOROMETHYLENEIMINIUM SALTS: METHODS OF GENERATION AND APPLICATIONS
  • 1.1 INTRODUCTION
  • 1.2 REACTIONS OF CHLOROMETHYLENEIMINIUM SALTS WITH TERTIARY ALCOHOLS
  • 1.3 CHLOROMETHYLENEIMINIUM SALTS: REACTIONS WITH ALKENES
  • 1.4 REACTIONS OF CARBINOLS DERIVED FROM ACYL KETENEDITHIOACETALS
  • 1.5 CHLOROMETHYLENEIMINIUM SALTS: REACTIONS WITH CARBONYL COMPOUNDS
  • 1.5.1 Reactions of Acyclic Ketones with Chloromethyleneiminium Salts
  • 1.5.2 Reactions of Cyclic Ketones with Chloromethyleneiminium Salts
  • 1.5.3 Reactions of α, β-Unsaturated Acyclic Ketones with Chloromethyleneiminium Salts
  • 1.5.4 Reactions of α, β-Unsaturated Cyclic Ketones with Chloromethyleneiminium Salts
  • 1.5.5 Reactions of Acyclic 1, 3-Diketones with Chloromethyleneiminium Salts
  • 1.5.6 Reactions of Cyclic 1, 3-Diketones with Chloromethyleneiminium Salts
  • 1.6 IMINIUM SALT MEDIATED SYNTHESIS OF PYRIDINES
  • 1.7 REACTIONS OF TERTIARY ALCOHOLS WITH VILSMEIER REAGENT FOLLOWED BY AMMONIUM ACETATE: SYNTHESIS OF FUNCTIONALIZED PYRIDINES AND NAPHTHYRIDINES
  • 1.7.1 Reactions of 2-Aryl-2 propanols with Chloromethyleneiminium Salt Followed by Ammonium Acetate
  • 1.7.2 Reaction of 2 Methyl-4 phenyl-3-buten-2-ol with Chloromethyleneiminium Salt Followed by Ammonium Acetate
  • 17.3 Reactions of 2-Aryl-2-butanols with Chloromethyleneiminium Salt Followed by Ammonium Acetate
  • 1.7.4 Reactions of Aliphatic and Alicyclic Alcohols with Chloromethyleneiminium Salt Followed by Ammonium Acetate
  • 1.8 REACTIONS OF α-HYDROXYKETENEDITHIOACETALS WITH CHLOROMETHYLENEIMINIUM SALT FOLLOWED BY AMMONIUM ACETATE: SYNTHESIS OF 4-ARYL-2 (METHYLSULFANYL) PYRIDINES
  • 1.9 REACTIONS OF CARBONYL COMPOUNDS WITH CHLOROMETHYLENEIMINIUM SALT FOLLOWED BY AMMONIUM ACETATE: SYNTHESIS OF SUBSTITUTED PYRIDINES
  • 1.10 CONCLUSIONS
  • 1.11 REFERENCES
  • 2. VILSMEIER-HAACK REACTIONS OF TERTIARY ALCOHOLS: SYNTHESIS OF FUNCTIONALIZED PYRIDINES AND NAPHTHYRIDINES
  • 2.1 INTRODUCTION
  • 2.2 GENERAL METHODS FOR THE PREPARATION OF FUNCTIONALIZED PYRIDINES
  • 2.3 RESULTS AND DISCUSSION
  • 2.3.1 Reactions of 2-Aryl-2 propanols with Chloromethyleneiminium Salt Followed by Ammonium Acetate
  • 2.3.2 Reaction of 2 Methyl-4 phenyl-3-buten-2-01 with Chloromethyleneiminium Salt Followed by Ammonium Acetate
  • 2.3.3 Reactions of 2 Aryl-2-butanols with Chloromethyleneiminium Salt Followed by Ammonium Acetate
  • 2.4 REACTIONS OF ALIPHATIC AND ALICYCLIC TERTIARY ALCOHOLS WITH CHLOROMETHYLENEIMINIUM SALT: SYNTHESIS OF FUNCTIONALIZED NAPTHYRIDINES
  • 2.4.1 Reaction of tent-Rutanol with Chloromethyleneimmium Salt Followed by Ammonium Acetate
  • 2.4.2 Reaction of 2 Methyl-2-butanol with Chloromethyleneiminium Salt Followed by Ammonium Acetate
  • 2.4.3 Reaction of 3 Methyl-3 pentanol with Chloromethyleneiminium Salt Followed by Ammonium Acetate
  • 2.4.4 Reaction of 1-Methyl-1-cyclohexanol with Chloromethyleneiminium Salt Followed by Ammonium Acetate
  • 2.5 CONCLUSIONS
  • 2.6 EXPERIMENTAL
  • 2.6.1 General Procedure for the Preparation of 2-Aryl-2 propanols from Substituted Acerophenones
  • 2.6.2 Reactions of Substituted 2-Aryl-2 propanols with Vilsmeier Reagent Followed by Ammonium Acetate: Synthesis of 4 Arylnicotinaldehydes
  • 2.6.3 Reaction of 2-Methyl-0 phenyl-3-buten-2-ol with Vilsmeier Reagent Followed by Ammonium Acetate: Synthesis of 4- (Phenyl vinyl) nlcotinaldehyde
  • 2.6.4 Preparation of 2 Aryl-2-butanols: General Procedure
  • 2.6.5 Reactions of 2 Aryl-2-butanols with Vilsmeier Reagent Followed by Ammonium Acetate: Synthesis of 4Aryl-5-methylnicotinaldehydes
  • 2.6.6 General Procedure for the Preparation of Aliphatic and Alicyclic Tertiary Alcohols from Ketones
  • 2.6.7 Reactions of Aliphatic and Alicyclic Tertiary Alcohols with Vilsmeier Reagent Followed by Ammonium Acetate: Synthesis of Substituted [2, 7]Naphthyridines
  • 2.7 REFERENCES
  • 3. REACTIONS OF FUNCTIONALIZED KETENEDITHIOACETALS WITH VILSMEIER REAGENT: SYNTHESIS OF ARYL ALKYLTHIOPYRIDINES
  • 3.1 INTRODUCTION
  • 3.2 α-OXOKETENEDITHIOACETALS: SYNTHESIS
  • 3.3 α-OXOKETENEDITHIOACETALS: REACTIVITY
  • 3.3.1 Synthesis of Pyridines from Ketenedithioacetals: General Methods
  • 3.3.2 Synthesis of Alkylthio Pyridines: Alternative Approaches
  • 3.4 RESULTS AND DISCUSSION
  • 3.4.1 Reactions of 2-Aryl-4, 4-bis (methylsulfanyl) -3-buten-2-ols with Chloromethyleneiminium Salt f allowed by Ammonium Acetate
  • 3.5 CONCLUSIONS
  • 3.6 EXPERIMENTAL
  • 3.6.1 General Procedure for the Preparation of α-Hydroxy ketenedithioacetals from α-Oxoketenedithioacetals
  • 3.6.2 Reactions of α-Hydroxy ketenedithioacetals with Vilsmeier Reagent Followed by Ammonium Acetate; Synthesis of 4 Aryl-2- (methylsulfanyl) pyridines
  • 3.7 REFERENCES
  • 4. REACTIONS OF CARBONYL COMPOUNDS WITH CHLOROMETHYLENEIMINIUM SALTS: SYNTHESIS OF SUBSTITUTED PYRIDINES
  • 41 INTRODUCTION
  • 4.2 GENERAL METHODS FOR THE SYNTHESIS OF CHLOROSUBSTITUTED PYRIDINECARBOXALDEHYDES AND RELATED COMPOUNDS
  • 4.3 GENERAL METHODS FOR THE SYNTHESIS OF SUBSTITUTED PYRIDINES
  • 4.4 THE REACTIVITY OF BENZYL METHYL KETONES TOWARDS ELECTROPHILIC REAGENTS
  • 4.5 RESULTS AND DISCUSSION
  • 4.5.1 Reactions of 1 Aryl-2 propanones with Chloromethyleneiminium Salt Followed by Ammonium Acetate
  • 4.5.2 Reaction of Benzyl Ethyl Ketone with Chloromethyleneiminium Salt Followed by Ammonium Acetate
  • 4.5.3 Reaction of Dibenzyl Ketone with Chloromethyleneiminium Salt Followed by Ammonium Acetate
  • 4.5.4 Reaction of Acyl Ketenedithioacetal with Chloromethyleneiminium Salt Followed by Ammonium Acetate
  • 4.6 CONCLUSIONS
  • 4.7 EXPERIMENTAL
  • 4.7.1 Reactions of Substituted Phenyl Acetones with Vilsmeier Reagent Followed by Ammonium Acetate: Synthesis of 5-Aryl-4-chloronicotinaldehydes
  • 4.7.2 Reaction of 1-Phenyl-2-butanone with Vilsmeier Reagent Followed by Ammonium Acetate: Synthesis of 4-Chloro-3-methyl-5 phenylpyridine
  • 4.7.3 Reaction of Dibenzyl Ketone with Vilsmeier Reagent Followed by Ammonium Acetate Synthesis of 3, 5-Biphenyl-4- (N, N-dimethylamino) pyridine
  • 4.7.4 Reaction of 4, 4-Bis (methylsulfanyl) -3 phenyl-3-buten-2-one with Vilsmeier Reagent Followed by Ammonium Acetate: Synthesis of 4-Chloro-2- (methylsulfanyl) -3 phenylp vridine
  • 4.8 REFERENCES