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Title
DECLARATION
CERTIFICATE
ACKNOWLEDGEMENT
CONTENTS
List of abbreviations
I Introduction and Review of literature
INTRODUCTION
REVIEW OF LITERATURE
I METASTASIS
1. The metastatic cascade
1.a. Circulating tumour cell arrest and extravasation
1.b. Basement membrane disruption during transition from in situto invasive tumours
1.b.a. Matrix metalloproteinases (MMP)
1.b.bSerine proteinases
1.b.c Cysteine proteinases
1.b.d Aspartyl prmteinases
1.b.e. Tissue Inhibitors of metalloproteinases
1.c Cell - Cell and cell-matrix interactions during tumourmetastasis
1.d Ibmour cell - Endothelial cell Interaction
1.e Angiogenesis
1.f. Tumour cell motility factors
2. Molecular Genetics - of Metastases
II HOST IMMUNE RESPONSES TO TUMOURS
I.a Specific Immune Responses
I.b Antibody dependent cell medicated cytoloxicity (ADCC)
I.c Complement dependent cytotoxicity
2.a Non specific Immune Responses
2.b Macrophage mediated cytolysis
2.c Natural killer cells (NK cells)
2.d Lymphokine activated killer cells (LAK)
2.e Cytokines
III Cytokines and tumour metastasis
IV Immunotherapy
V Adoptive Immunotherapy
VI Plant products as immunomodulators in tumour therapy.
Viscunl album
Curcumin (Diferuloyl methane)
II Materials and methods
A. MATERIALS
I. Test Compounds
II. Chemicals
III. Reagents
IV. Animals
V. Cell lines
VI. Instruments
B. METHODS
I. Tissue Culture
II. Maintenance of Experimental Animals.
III. Maintenance of tumours in animals.
IV. Preparation of B16F-10 cells for in vivo studies.
V. Preparation of cells for in vitro studies.
VI. Determination of cell viability
VII. In vitro cytotoxicity studies
VIII.Long term ill vitro cytotoxicity studies by tissue culture.
IX. Hematological Parameters
X. Immunological Parameters
XI. ANTIMETASTATIC STUDIES
XII. Statistical Analysis
III Immunomodulatory and antimetastatic activity of - different plant extracts Preliminary screening
3.1 Introduction
3.2 Materials and Methods
3.3 Results
Table III-1 In vitro cytotoxicity of immunomodulators
TABLE III-2 Effect of imrnunornodulators on circulating antibody titre.
TABLE III-3 Effect of immunomodulators in the inhibition of lung metastasis
3.4 Discussion
IV Antimetastatic activity of Iscador -in vivo and - in vitro studies
4.1 Introduction
4.2 Materials and Methods
In vivo Antimetastatic Studies
In vitro antimetastatic studies.
4.3 Results
4.4 Discussion
Fig. 4.1: Effect of Iscador on gelatin substrate gelelectrophoresis:
V Adoptive immunotherapy using Iscador
5.1 Introduction
5.2. Materials and Methods
5.3 Results
Fig. 5.1: Histopathological analysis of lung tissue of metastatic tumour bearing animals treated with adoptive irnrnunotherapy.
5.4 Discussion
VI Effect of Iscador on cell mediated immune - responses during tumour cell metastasis
6.1 Introduction
6.2 Materials and Methods.
6.3 Results
Fig. 6.1 Effect of Iscador on macrophage mediated lysis
6.4 Discussion
VII Immunomodulatory and myeloprotective effects of curcumin
7.1 Introduction
7.2 Materials and Methods
7.3 Results
IMMUNOMODULATORY EFFECTS OF CURCUMIN
Myeloprotective Effects of Curcumin
7.4 Discussion
VIII Effect of curcumin on cell mediated immune responses during tumour cell metastasis
8.1 Introduction
8.2 Materials and Methods.
8.3 Results
8.4 Discussion
IX Summary and conclusion
References