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Thesis Details
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Title
Declaration
Certificate
Dedication
Acknowledgement
Contents
Abstract
Preface
List of Tables
List of Figures
Abbreviations
1. Introduction and review of literature
1.2. How does radiation interact with cells
1.3. The role of ROS in normal physiology
1.4. Effects of radiation on biological system
1.5. Cellular defense mechanisms against radiation-induced oxidative stress
1.6. Necessity of radioprotecting agents
1.7. Radiomodulators: definition and types
1.8. Radioprotective drug development initiatives
1.9. Antioxidants as radioprotectors
1.10. Ascorbic acid (Vitamin c)
1.11. As AG (Ascorbic acid-2-glucoside)
2. Materials and Methods
3. Free radical scavenging and anti-inflammatory activities of Ascorbic acid-2 glucoside
4. Tissue protective efficacy of Ascorbic acid-2 glucoside against γ-radiation-induced damages in mice
5. Radio protection by Ascorbic acid-2-Glucoside at the molecular level: Protection of membrane lipids and DNA against γ-radiation
6. Radio protection by Ascorbic acid 2-Glucose assessed by cytogenetics parameters
7. Enhancement in repair of radiation-induced DNA strand breaks by Ascorbic acid-2 Glucoside
8. Amelioration of side effects of cancer chemotherapeutic drug, Cisplatin, by Ascorbic acid-2 Glucoside in mice
9. Studies on the use of Ascorbic acid 2- Glucoside as an adjuvant in radiotherapy in mouse model
Summary and Conclusion
Bibliography