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TITLE
CERTIFICATE
DECLARATION
ACKNOWLEDGEMENT
CONTENTS
ABBREVIATIONS
1. INTRODUCTION AND REVIEW OF LITERATURE
1.1 INTRODUCTION
Fig 1.1 Pleurotus florida
Fig 1.2 Pleurotus sajor-caju
1.2 REVIEW OF LITERATURE
1.2.1. MUSHROOMS
Table 1.1. Anti-cancer drugs developed from mushrooms
Table 1.2. Reported benefits of medicinal mushrooms
1.2.2 OYSTER MUSHROOMS
1.2.3 FREE RADICALS
Table 1.3 Biologically significant free radicals
Fig 1.3. The active oxygen system
1.2.4 SOURCES OF FREE RADICALS
1.2.5 DAMAGE PRODUCED BY FREE RADICALS
1.2.6 PROTECTION AGAINST OXYGEN RADICALS
1.2.7 CANCER
Table 1.4: Known chemical carcinogens
Table 1.5: Hard and soft materials, of different shape anddimension, found to be carcinogenic when implanted into rodents
Table 1.6: Tumour suppressor genes associated withhuman tumours
1.2.8 TREATMENTS OF CANCER
Fig 1.4: Formation of cancer cells
Fig. 1.5 Stages of Carcinogenesis
2. MATERIALS AND METHODS
2.1 MATERIALS
2.2 METHODS
2.3 STATISTICAL ANALYSIS
3. ANTIOXIDANT ACTIVITY OF THE EXTRACTS OF PLEUROTUS FLORIDA AND PLEUROTUS SAJOR-CAJU
3.1 INTRODUCTION
3.2 MATERIALS AND METHODS
3.3 STATISTICAL ANALYSIS
3.4 RESULTS
Table 3.1. In vitro antioxidant activity of extracts of P.florida (IC50μg/ml)
Table 3.2. In vitro antioxidant activity of extracts of P.sajor-caju IC50 (μg/mL)
3.5 DISCUSSION
4. ANTI INFLAMMATORY AND PLATELETAGGREGATION INHIBITING ACTIVITIES OF PLEUROTUS FLORIDA AND PLEUROTUS SAJOR-CAJU
4.1 INTRODUCTION
4.2 MATERIALS AND METHODS
4.3 RESULTS
Table 4.1. Effect of methanolic extract of P. florida andP.sajor-caju on carrageenan induced acute inflammation
Table4.2: Effect of methanolic extract of P. florida and P.sajor-caju on formalin induced chronic inflammation
Fig 4.7 Antiinflammatory activity of methanolic extract of P.florida
Fig 4.8 Antiinflammatory activity of methanolic extract of P.sajor-caju
4.4 DISCUSSION
5. ANTICARCINOGENIC ACTIVITY OF THE METHANOLIC EXTRACTS OF PLEUROTUS FLORIDA AND P PLEUROTUS SAJOR- CAJU
5.1 INTRODUCTION
5.2 MATERIALS AND METHODS
5.3 RESULTS
Fig 5.1: Effect of methanolic extract of P.florida
Fig 5.4: Effect of methanolic extract of P.sajor-caju
5.4 DISCUSSION
6. ANTITUMOUR ACTIVITY OF THE METHANOLIC EXTRACTS OF PLEUROTUS FLORIDA AND PLEUROTUS SAJOR-CAJU
6.1 INTRODUCTION
6.2 MATERIALS AND METHODS
6.3 RESULTS
Table 6.1: Effect of methanolic extract of P.florida on solid tumor
Table 6.2: Effect of methanolic extract of P.sajor-caju on solid tumor
Table 6.3: Antitumor activity of methanolic extract of P.florida on developed tumor
Table 6.4: Antitumor activity of methanolic extract of P.sajor-caju on developed tumor
Fig 6.3: Antitumour activity of methanolic extract of P.florida
Fig 6.4: Antitumour activity of methanolic extract of P.sajor-caju
6.4 DISCUSSION
7. HEPATO PROTECTIVE EFFECT AND IN VIVO ANTIOXIDANT ACTIVITY OF THE EXTRACTS OFPLEUROTUS FLORIDA AND PLEUROTUS SAJOR-CAJU
7.1 INTRODUCTION
7.2 MATERIALS AND METHODS
7.3 RESULTS
Table 7.1 Effect of methanolic extract of P.florida on serum GOT, GPT and ALP activities consequent to CCl4 challenge
Table 7.2. Effect of methanolic extract P.sajor- caju on serum GOT, GPT and ALP activities consequent to CCl4 challenge
Table 7.3 Effect of methanolic extract P.florida on liver SOD, GPx and CAT activities consequent to CCl4 challenge
Table 7.4. Effect of methanolic extract P.sajor-caju on liver SOD, GPx and CAT activities consequent to CCl4 challenge
Fig 7.5: Hepatoprotective activity of methanolic extract of P.florida
Fig 7.6: Hepatoprotective activity of methanolic extract of P.sajor-caju
7.4.DISCUSSION
8. NEPHRO PROTECTIVE EFECT AND PREVENTION OF DRUG INDUCED OXIDATIVE DAMAGE BY THE EXTRACTS OF PLEUROTUS FLORIDA AND PLEUROTUS SAJOR-CAJU
8.1 INTRODUCTION
8.2 MATERIALS AND METHODS
8.3 RESULTS
Table 8.1: Effect of methanolic extract of P.florida on the increase in serum urea and creatinine levels induced by cisplatin administration
Table 8.2: Effect of methanolic extract of P. sajor-caju on the increase in serum urea and creatinine levels induced by cisplatin administration
Table 8.3: Effect of methanolic extract of P.florida on renal SOD, CAT and GPx activities induced by cisplatin
Table 8.4: Effect of methaiiolic extract of P. sajor-cajcr on renal SOD, CAT and GPx activities induced by cisplatin
Tables8.5: Effect of cisplatin, cisplatin + methanolic extract of P-floridaon solid tumour
Table 8.6: Effect of cisplatin, cisplatin + methanolic extract of P.sajor-caju on solid tumour
8.4 DISCUSSION
SUMMARY AND CONCLUSION
BIBLIOGRAPHY
LIST OF PUBLICATIONS